Progress of immunologic derangement in the pathogenesis of primary nephritic syndrome
10.3760/cma.j.issn.1673-4408.2011.01.024
- VernacularTitle:免疫紊乱在原发性肾病综合征发病机制中的研究进展
- Author:
Yongchang YANG
- Publication Type:Journal Article
- Keywords:
Immunologic derangement;
T regulatory cell;
Primary nephritic syndrome
- From:
International Journal of Pediatrics
2011;38(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Help T cell 1/Help T cell 2 and some cytokines disequilibrium can give a suitable explanation for hypersensitivity and hypogammaglobulinemia in primary nephritic syndrome(PNS) patients. The disturbance of regulatory T cell(Treg cell) and Th17 cell can lead to correlated cytokines derangement, which explained the pathogenesis of PNS from another aspect. Refractory nephrotic syndrome can be effectively treated by rituximab followed the percentage of regulatory T cell increasing, which indicated that Treg may play an important role in pathogenesis of PNS.
