Effect of esmolol on bispectral index in patients undergoing orotracheal intubation during induction of anesthesia
- VernacularTitle:艾司洛尔对患者麻醉诱导气管插管时脑电双频谱指数的影响
- Author:
Dequan CAO
;
Yanping CHEN
;
Yanling ZHANG
;
Yetian CHANG
- Publication Type:Journal Article
- Keywords:
propanolamines;
electroencephalogrphy;
hemodynamic phenomena;
intubation,intratracheal
- From:
Chinese Journal of Anesthesiology
2010;30(z1):13-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of esmolol on bispectral index (BIS) in patients undergoing orotracheal intubation during induction of anesthesia and to investigate the mechanism of inhibiting the cardiovascular responses to tracheal intubation.Methode Forty patients in physical status of ASA Ⅰ or Ⅱ and aged 20-60 years were randomly divided into 2 groups ( n = 20 each): esmolol group (group E) and control group (group C). Anesthesia was induced with midazolam 0.1 mg/kg, fentanyl 5 μg/kg and vecuronium 0.1 mg/kg. In group E, esmolol 1 mg/kg was given intravenously before anesthesia induction and followed by an infusion of esmolol 250 μg· kg- 1·min-1, while a comparable volume of saline was given for group C. Mean arterial pressure (MAP), heart rate (HR) and BIS were recorded before esmolol administration, before induction of anesthesia, before orotracheal intubation, and at 1, 2 and 5 min after intubation, respectively.Results There were no significant differences in HR, MAP and BIS between the two groups before tracheal intubation. HR and MAP significantly increased after tracheal intubation in both groups, but BIS only in group C significantly increased after intubation.HR, MAP and BIS were significantly lower after intubation in group E than in group C ( P＜ 0.05).Conclusion Esmolol can decrease BIS during tracheal intubation and its antinociceptive property is related to the mechanism of inhibiting cardiovascular responses to tracheal intubation.
