Effects of adenosine preconditioning on expression of myocardial TNF-a mRNA and ICAM-1 mRNA in patients undergoing off-pump coronary artery bypass graft operation
- VernacularTitle:腺苷预处理对非体外循环冠状动脉旁路移植术患者心肌TNF-αmRNA和ICAM-1mRNA表达的影响
- Author:
Jing YANG
;
Daxuan YANG
;
Jue YE
;
Yi ZHANG
;
Lihuan LI
- Publication Type:Journal Article
- Keywords:
adenosine;
tumor necrosis factor-alpha;
cell adhesion molecules;
coronary artery bypass,off-pump;
ischemic preconditioning
- From:
Chinese Journal of Anesthesiology
2010;30(z1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of adenosine preconditioning on the expression of myocardial tumor necrosis factor-alpha (TNF-α) mRNA and intercellular adhesion molecule-1 (ICAM-1) mRNA in patients undergoing off-pump coronary artery bypass graft (OPCABG).Methods Forty patients, aged 44-68 yr, with more than three coronary artery obstructions and the ejection fraction≥40%,undergoing elective OPCABG, were randomly divided into 2 groups (n=20 each): control group and adenosine group. Adenosine group received adenosine preconditioning, with the initial infusion rate of 50 μg. kg-1.min-1, then increasing to 100μg.kg-1.min-1after 1 min, finally increasing to 150 μg. kg-1 . min-1 after 2 min and maintaining for 7 min. Vascular anastomosis was started at 5 min after preconditioning. While the control group received normal saline instead of adenosine. Tissue samples of the right auricle were taken before preconditioning (baseline) and at 15 min after blood current retum to measure the expression of myocardial TNF-α mRNA and ICAM-1 mRNA. The myocardial ultrastructure was observed and hemodynamic parameters were monitored.Results The myocardial damage was milder in the adenosine group than in the control group. The expression of myocardial TNF-α mRNA and ICAM-1 mRNA was significantly lower in the adenosine group than in the control group ( P＜0.05).Conclusion Adenosine preconditioning can attenuate myocardial ischemia-reperfusion injury in patients undergoing OPCABG through down-regulating the expression of myocardial TNF- mRNA and ICAM-1 mRNA.
