MTA1 in tumor progression and metastasis
10.3760/cma.j.issn.1673-4203.2011.01.018
- VernacularTitle:MTA1与肿瘤转移的研究进展
- Author:
Xingguo YANG
;
Zhixia LI
- Publication Type:Journal Article
- Keywords:
MTA1;
Metastasis-associated gene;
Nucleosome remodeling histone deacetylase
- From:
International Journal of Surgery
2011;38(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
MTA1 is a composition of Nurd,which may deacetylate histone and non-histone to affect gene transcription and protein expression. Since it is often overexpressed in many tumors and closely related to invasion,metastasis and prognosis of the malignancy, MTA1 might be exploited as a tumor marker for clinical application. This article reviews the structure and function of MTA1 and some new research progress on the tumor metastasis related to MTA1.
