Progress in revealing mechanism of anti-angiogenesis effects of bisphosphonates
10.3760/cma.j.issn.1673-422X.2010.11.010
- VernacularTitle:双膦酸盐抗血管形成机制研究进展
- Author:
Wanlan HUANG
- Publication Type:Journal Article
- Keywords:
Diphosphonates;
Angiogenesis inhibitors
- From:
Journal of International Oncology
2010;37(11):831-835
- CountryChina
- Language:Chinese
-
Abstract:
Bisphosphonates have shown direct anti-tumor and anti-angiogenesis effects, but the exact mechanism has not yet been elucidated. Based on the existing findings, some mechanisms related to the inhibition of vascularization has been proposed. First, bisphosphonates inhibit the differentiation of endothelial progenitor cells by interfering with the key enzyme in the mevalonate pathway which plays an important role in the prenylation of small G-proteins. Second,bisphosphonates impair the proliferation,adhesion and migration of endothelial cells. Last, bisphosphonates are able to regulate secretion of cytokines which are involved in angiogenesis and inhibit the functions of angiogenesis-related genes.
