Effect of Panax quinquefolium saponins from steams and leaves on acidosis and the metabolism of free radical in focal cerebral ischemia injury rats

VernacularTitle:西洋参茎叶皂苷对局灶性脑缺血大鼠脑组织酸中毒及自由基代谢的影响
Author: Fengguo ZHAI ; Lixin GUAN ; Haihua BAO ; Shufen GUO
Publication Type:Journal Article
Keywords: Panax quinquefolium saponins from steams and leave; Cerebral ischemia; Acidosis; Free radical
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(1):4-6
CountryChina
Language:Chinese
Abstract: Objective To investigate the protective effct of Panax quinquefolium saponins from steams and leaves(PQS)on focal cerebral ischemia injury in rats and its mechanisms. Methods Wistar rats were randomly divided into sham operation group,model control group,nimodipine group and two PQS groups,in which PQS of 100 and 50 mg/kg was intragastrically administered. Focal cerebral ischemia model was established by middle cerebral artery occlusion (MCAO)in rats, via string ligation of artetia carotis interna. The content of malondicldehy de(MDA) was determined by thibabituric acid ( TBA ) test, the activity of lactate dehydrogenase ( LDH ), superoxide dismutase (SOD)and the content of lactic acid(LA) were detected by chemical colorimetry test in cerebral tissues. Results PQS( 100,50mg/kg)could significantly decrease the content of LA、MDA and increase the activity of LDH、SOD. Conclusion The protective mechanism of PQS on focal cerebral ischemia injury may be related to reduce acidosis, anti-free radical and resist oxidative damage.