Expression and function of P2X purine receptors in the enteric nervous system
10.3760/cma.j.issn.1673-4203.2011.01.012
- VernacularTitle:P2X嘌呤受体在肠神经系统中的表达及功能
- Author:
Hua ZHU
;
Wei PENG
- Publication Type:Journal Article
- Keywords:
ATP;
P2X receptor;
Enteric nervous system
- From:
International Journal of Surgery
2011;38(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
P2X receptors are ligand gated ion channels, extracellular ATP is their natural extracellular ligand. When any of the subtypes of P2X receptors and extracellular ATP are combined, P2X channel opens, allowing cations (calcium, sodium, potassium, etc. ) pass through. Enteric nervous system is composed of the gut myenteric plexus and submucosal plexus, in both of which P2X receptors exist, mediating different effects under physiological and pathological conditions. In this paper, the enteric nervous system,P2X receptor distribution and related functions are reviewed in order to further explore the P2X receptor in the diagnosis and treatment of intestinal diseases.
