Progress on pathogenesis of essential thrombocythemia
10.3760/cma.j.issn.1673-4408.2011.01.011
- VernacularTitle:原发性血小板增多症发病机制研究进展
- Author:
Wenwen FAN
- Publication Type:Journal Article
- Keywords:
Essential thrombocythemia;
Pathogenesis
- From:
International Journal of Pediatrics
2011;38(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Essential thrombocythemia (ET) which is a clonal disease of hematopoietic stem cell mainly reflects hyperplasia of megakaryocyte. Childhood ET is characterized by persistance of thrombocytosis, mild to moderate hepatomegalia and splenomegalia, thrombogenesis and hemorrhage complications. The pathogenesis of ET is obviously associated with the abnormal or disturbance expression of multiple genes, micro RNAs,immunological molecules and some chromosome aberration. This review will focus on recent developments in the pathogenesis of ET in molecular biology, immunology and cytogenetics.
