Plasma kisspeptin levels in normal female pubertal stages and in girls with idiopathic central precocious puberty
10.3760/cma.j.issn.1000-6699.2011.01.011
- VernacularTitle:女童特发性中枢性性早熟及正常女性青春发育各期血浆kisspeptin水平研究
- Author:
Xiaoyu MA
;
Jihong NI
;
Yuejun LIU
;
Shaoke CHEN
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Kisspeptin;
Idiopathic central precocious puberty;
Premature thelarche;
Tanner stages;
Female
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pattern of plasma kisspeptin levels in normal female during various pubertal Tanner stages and the girls with idiopathic central precocious puberty(ICPP) or with premature thelarche(PT), and to evaluate the significance of detecting plasma kisspeptin levels as a new criterion for early differentiation between ICPP and PT.Methods Each study group of normal pubertal females with Tanner stage Ⅰ to Ⅴ comprised 16 to 19 individuals.The levels of plasma kisspeptin were also detected in girls with ICPP(n= 10)or PT(n = 12).The plasma kisspeptin levels were detected by enzyme-linked immunosorbent assay (ELISA).Results The level of kisspeptin was significantly higher in ICPP group than in that of PT group [(1.73±0.23 vs1.43±0.29) ng/ml, P<0.05].Among the normal pubertal females, the level of kisspeptin decreased gradually from Tanner stage Ⅱ to Tanner stage Ⅴ, being highest in Tanner stage Ⅱ [(1.73±0.22) ag/ml] ,lower in stage Ⅳ and Ⅴ than in stage Ⅰ and Ⅲ (P<0.01).Conclusions Plasma kisspeptin level was the highest during Tanner stage Ⅱ in normal female pubertal development.It is significant to detect plasma kisspeptin level for the differential diagnosis of ICPP and PT.