Relationship between inflammatory response induced by cardiopulmonary bypass and postoperative cognitive dysfunction
10.3760/cma.J.issn.0254-1416.2010.10.003
- VernacularTitle:体外循环诱发炎性反应与患者术后认知功能障碍的关系
- Author:
Zhenyuan WANG
;
Shuming WU
;
Ye LIU
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Cognition disorders;
Postoperative complications;
Inflammation
- From:
Chinese Journal of Anesthesiology
2010;30(10):1160-1162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the relationship between inflammatory response induced by cardiopulmonary bypass and postoperative cognitive dysfunction.Methods Twenty-five patients undergoing elective cardiac valve replacement under cardiopulmonary bypass were randomly divided into two groups:ulinastatin group(group U,n=13) and control group(group C,n=12).In group U,ulinastatin 12 000 U/kg Was given intravenously immediately after induction of anesthesia,6 000 U/kg ulinastatin Was added to the priming solution,and 6000 U/kg ulinastatin was given at 5 min before the aortic decamping.In group C,normal saline was given instead of ulinastatin.Venous blood samples were taken after induction of anesthesia,at the end of CPB,and 24 h after operation for determination of plasma IL-6 concentration and neutrophils NF-kB expression.The cognitive function of the patients was evaluated by Mini-Mental State Examination(MMSE) before and 3 d,7 d after operation.Results The concentraion of IL-6 and neutrophils NF-kB expression were lower in group U than in group C(P<0.05 or 0.01).There wag no significant difference in the incidence of postoperative cognitive dysfunction between group C and U.Conclusion Inflammatory response induced by cardiopulmonary bypass is not related to postoperative cognitive dysfunction.
