Role of Wnt/β-catenin signaling pathway in impaired wound healing of diabetes mellitus
10.3760/cma.j.issn.1000-6699.2011.01.017
- VernacularTitle:Wnt/β-catenin信号通路在糖尿病创面难愈中的作用
- Author:
Xiaolei SUN
;
Yong LIU
;
Meihong SHI
;
Wu ZHONG
;
Hong ZENG
;
Hui YANG
;
Sen SHI
;
Xiangyu ZHOU
;
Lixia NIE
;
Yanzheng HE
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Wound healing;
Wnt/β-catenin
- From:Chinese Journal of Endocrinology and Metabolism
2011;27(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of Wnt/β-catenin signaling pathway in impaired wound healing of diabetes mellitus.Methods The back skin defect was produced in rats with type1diabetes.All of these rats were divided into normal group, diabetes group, lithium chloride group, and epidermal growth factor (EGF) group.The back wound healing and β-catenin expression were observed.Results There were no signs of infection in the wound of rats after injury.Compared with diabetic group, the wound healing time was shorter,wound healing rate was higher, wound cavity volume was smaller, granulation tissue was more mature, and β-catenin positive cell rate was higher in normal group, lithium chloride group, and EGF group(P＜0.05 or P＜0.01).Conclusions Wnt/beta-catenin signaling pathway is involved in the process of wound healing in diabetic rats.
