The prognostic value of KISS1 expression of gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2011.01.004
- VernacularTitle:KISS1蛋白在胃肠道间质瘤中的表达及其预后预测意义
- Author:
Qiwei XIE
;
Shijie LI
;
Kewei JIANG
;
Yingjiang YE
;
Shan WANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Gene expression;
Pathology,clinical;
Neoplasm metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
2011;26(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate KISS1 expression, and its significance in the prognosis of GIST patients. Methods In this study, 137 GIST cases and 73 non-GIST sarcoma cases were evaluated for clinicopathological characteristics and immunohistochemistry for KISS1 antibodies. Result The expression rate of KISS1 was 40.9% (56/137) in GISTs,which was significantly correlated with tumor size, disease extent, cellularity, presence of pseudocapaule, Fletcher's risk stratification and metastatic status after resection (P＜0.05). Patients with positive KISS1 expression had significantly worse disease free survival and disease specific survival (P ＜ 0.05 ). Conclusions KISS1 expression was associated with some clinicopathological characteristics as well as malignant behaviors in patients with GISTs. KISS1 might be a predictor in prognosis for GIST patients.
