Correlation between Aurora-A and breast carcinoma treatment efficacy of paclitaxel
10.3760/cma.j.issn.1673-4904.2011.03.009
- VernacularTitle:Aurora-A与乳腺癌紫杉醇化疗疗效相关性研究
- Author:
Chunxia PAN
;
Xiumei ZHANG
;
Xiaohui XU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Paclitaxel;
Aurora-A
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(3):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Aurora-A in breast carcinoma and the relationship with breast carcinoma treatment efficacy of paclitaxel. Methods The expression of Aurora-A were tested by immunohistochemical SP method in 67 cases of breast carcinoma. The relationship of Aurora-A with treatment efficacy of paclitaxel was analysed. Results The expression rate of Aurora-A was 73.13%(49/67)in breast carcinoma. The treatment effective rate of breast carcinoma was 77.78%(14/18) and the rate of nonresponder was 11.11%(2/18) in negative expression of Aurora-A;but the treatment effective rate was 34.69%(17/49) and the rate of nonresponder was 34.69%(17/49) in positive expression of Aurora-A. There were obvious correlations between expression of Aurora-A and treatment efficacy of paclitaxel. Statistical significance could be found between them (P = 0.013 ). Conclusion There is manifest correlation between the high expression of Aurora-A and resistance of paclitaxel in breast carcinoma.
