A review on the gene of the caudal-type homeobox gene -2 in leukemia
10.3760/cma.j.issn.1673-4408.2011.01.030
- VernacularTitle:CDX2基因与白血病关系的研究进展
- Author:
Yingxia LI
- Publication Type:Journal Article
- Keywords:
Caudal-type homeobox gene-2;
Leukemia;
Homeobox gene;
Minimal residual disease
- From:
International Journal of Pediatrics
2011;38(1):85-88
- CountryChina
- Language:Chinese
-
Abstract:
The gene of the caudal-type homeobox gene -2 ( CDX2), a member of the CDX family, is a principal regulator in the development of embryogenesis and haematogenesis . Recent studies have shown aberrant expression of CDX2 in each subtype of leukemia and its involvement in the genesis, progress and prognosis of leukemia as new gene. CDX2 may be a potential gene maker of leukemia in minimal residual disease detection.Studies also suggested that CDX2 be involved in leukemia by modulating HOX gene. To further investigate the mechanism of CDX2 in leukemia can be of great significance for the prediction of relapse and the individualized and targeted therapy.
