Brain injury and β-amyloid precursor protein, β-amyloid protein
10.3760/cma.j.issn.1673-4203.2011.01.019
- VernacularTitle:β淀粉样前体蛋白、β淀粉样蛋白与颅脑损伤研究进展
- Author:
Shukai WU
;
Junyan CHEN
;
Hongzhi GAO
- Publication Type:Journal Article
- Keywords:
β- amyloid precursor protein;
β- amyloid;
cognitive dysfunction;
traumatic brain injury;
diffuse axonal injury;
β-site APP-cheaving enzyme
- From:
International Journal of Surgery
2011;38(1):59-62
- CountryChina
- Language:Chinese
-
Abstract:
As a transmembrane protein, β-amyloid precursor protein(β-APP) distributes extensively in the central nervous system, has the effect of neurotrophic, and neuroprotective, promote neurite growth and synaptogenesis, β-amyloid(Aβ) is the digestion products of its precursor-APP in the pathological conditions, and it is the main component of senile plaques-the main pathological changes of Alzheimer' s disease (AD), its toxic effects can also induce neuronal apoptosis, The expression of the two proteins after brain injuried has a close relationship with the injury, cognitive dysfunction, Alzheimer' s disease and the pathophysiological changes of central nervous system. To explore its expression in the brain after traumatic brain injury can determine the degree of injury, assess the prognosis and open up new avenues for the treatment of traumatic brain injury.
