Effect of integrin signaling pathway on proliferation and migration of vascular smooth muscle cell
10.3760/cma.j.issn.1673-4408.2011.01.017
- VernacularTitle:整合素在血管平滑肌细胞增殖和迁移中的作用
- Author:
Cuixia LU
- Publication Type:Journal Article
- Keywords:
Integrin;
Vascular smooth muscle cell;
Proliferation;
Migration
- From:
International Journal of Pediatrics
2011;38(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Many cardiovascular diseases, such as pulmonary hypertension, atherosclerotic plaque formation and restenosis after angioplasty, are charaterized by vascular remodeling resulting from migration and proliferation of vascular smooth muscle cells. Integin receptors can activate the expression of related genes through the corresponding signal pathway, and lead to vascular smooth muscle cell' s proliferation and migration and other biological behavioral change, which may be a new hotspot of pathogenesis and intervention of vascular remodeling.
