Pigment epithelium-derived factor inhibits high glucose-stimulated transforming growth factor β1,fibronectin, and collagen Ⅳ expressions in human mesangial cells
10.3760/cma.j.issn.1000-6699.2011.01.020
- VernacularTitle:色素上皮衍生因子抑制高糖诱导的人肾小球系膜细胞转化生长因子β1、纤连蛋白和Ⅳ型胶原的表达
- Author:
Tuohua MAO
;
Jing LI
;
Huiqin LI
- Publication Type:Journal Article
- Keywords:
Pigment epithelium-derived factor;
Transforming growth factor β1;
Fibronectin;
Collagen Ⅳ
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(1):70-71
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of transforming growth factor β1 (TGF-β1), fibronectin (FN), and collagen Ⅳ in human mesangial cells were augmented with increased concentrations of glucose.Pigment epithelium-derived factor (PEDF) at concentrations of 40-160 nmol/L significantly inhibited TGF-β1 expression in a dose-dependent manner(P＜0.01).PEDF at concentrations of 5-40 nmol/L significantly decreased FN and collagen Ⅳ expressions in a dose-dependent manner(P＜0.01) ,suggesting that PEDF may play a salutary role in diabetic nephropathy by its antifibrogenic activity.
