Changes of oxygenate function in patients with multiple organ dysfunction syndrome during continuous venovenous hemofiltration by different dilution modes

VernacularTitle:不同稀释法连续性血滤对多器官功能不全综合征患者氧合功能的影响
Author: Huiyu LUO ; Changjiang XIE ; Yingming GU ; Feipeng CHEN
Publication Type:Journal Article
Keywords: Multiple organ failure; Hemofiltration
From: Chinese Journal of General Practitioners 2011;10(1):52-53
CountryChina
Language:Chinese
Abstract: Twenty eight patients with multiple organ dysfunction syndrome (MODS) underwent continuous venovenous hemofiltration (CVVH)in ICU from June 2003 to June 2008, including 13 cases treated with predilution mode and 15 with postdilution mode. The changes of oxygenate index( PaO2/FiO2 )during CVVH were retrospectively analyzed. The total case fatality rate of this group of patients was 46%(13/28). There was a significant increase in PaO2/FiO2 of 28 cases during the first 48 h of CVVH (P ＜0. 05);the levels of PaO2/FiO2 in predilution group had increased significantly within 48 h during CVVH (P＜0. 05), while those in postdilution group had not significantly changed (P ＞ 0. 05). There was a significant increase in Pa02/FiO2 for the survival patients during the first 48h CVVH( P ＜ 0. 05 ), while no significantly change in the fatal cases(P ＞0. 05 ). In summary, oxygenate function and outcome of patients with MODS can be improved by CVVH, and predilution may be a more effective mode.