Efficacy of dexmedetomidine versus midazolam for sedation in critically ill patients: a Meta-analysis

VernacularTitle:重症患者右美托咪啶和咪达唑仑镇静效果的比较:Meta分析
Author: Tao YU ; Liang DONG ; Songqiao LIU ; Yi YANG ; Haibo QIU
Publication Type:Journal Article
Keywords: Dexmedetomidine; Midazolam; Conscious sedation; Meta-analysis
From: Chinese Journal of Anesthesiology 2010;30(11):1297-1300
CountryChina
Language:Chinese
Abstract: Objective To systematically review the efficacy of dexmedetomidine or midazolam for sedation in critically ill patients. Methods We searched the PubMed, EMBaes, Cochrane Library, Wanfang Database,CNKI and VIP for all randomized controlled trials (RCTs) about the efficacy of dexmedetomidine versus midazolam for sedation in severe cases. The quality of the studies was evaluated by the method recommended by Cochrane Collaboration. Meta-analysis was conducted using the Cochrane Collaboration's RevMan 5.0 software. Results Six RCTs involving 613 patients were included in our Meta-analysis. The results of Meta-analysis showed that the length of ICU stay was significantly shorter in group dexmedetomidine than in group midazolam. There were no significant differences in the duration of mechanical ventilation, incidences of bradycardia, hypotension and delirium and mortality rate between the two groups. Conclusion Dexmedetomidin can shorten the length of ICU stay and is beneficial for the outcome in critically ill patients.