Quantitative assessment of blood perfusion in thyroid nodules by contrast-enhanced ultrasonography

VernacularTitle:超声造影定量分析对甲状腺结节血流灌注的研究
Author: Chen YANG ; Chaowen QIAN ; Huineng ZHU ; Gu ZHANG
Publication Type:Journal Article
Keywords: Ultrasonography; Microbubbles; Thyroid diseases
From: Chinese Journal of Ultrasonography 2011;20(1):38-40
CountryChina
Language:Chinese
Abstract: Objective To assess the value of blood perfusion of thyroid nodules using contrastenhanced ultrasonography(CEUS). Methods Blood perfusion parameters of 78 preoperative patients with thyroid nodule were examined using CEUS. Microvessel density(MVD) in the thyroid nodule specimens was calculated by immunohistochemical staining using anti-factor CD34. Results Compared to papillary thyroid carcinoma (PTC) and nodular goiter (NG), there was significant differences in peak value(PEAK),maximum value of video signal intensity(Slmax), and mean value of video signal intensity(SImean) in thyroid nodule with diameter ＜ 1 cm ( P ＜ 0. 05 ), the MVD of thyroid nodules was not statistically significant ( P ＞ 0.05). There were significant differences in regional blood volume and MVD in thyroid nodule with diameter ≥ 1 cm between two groups ( P ＜ 0.05). Conclusions The characteristics of blood perfusion are dissimilar for thyroid nodules with different sizes and properties. The quantitative analysis with CEUS can provide valuable information for clinical diagnosis.