Elastographic characterization of microwave-induced lesions in porcine liver

VernacularTitle:离体猪肝微波消融灶的弹性变化及其病理意义
Author: Jianquan ZHANG ; Zongping DIAO ; Feng LU ; Jianguo SHENG ; Jin HE
Publication Type:Journal Article
Keywords: Ultrasonography; Microwaves/therapeutic use; Liver
From: Chinese Journal of Ultrasonography 2011;20(1):76-79
CountryChina
Language:Chinese
Abstract: Objective To investigate the elasticity reduction of liver tissue due to microwave ablation and the relevance to the histographic damages. Methods An experimental study using fresh porcine liver was designed. Elasto-ultrasonography scanning both in color display and strain ratio calculations was conducted before and 5 min after microwave ablation ( 2450 MHz) in manner of antenna insertion under ultrasound guidance to determine the alterations of the liver elasticity, in correspondence with the histopathologic assessment of each ROI. Results Elasto-ultrasonography showed a significant elasticity reduction and hardness augment of the targeted liver tissue and the corresponding histopathology revealed increases in the amount of massive coagulative necrosis and coking of liver cells after microwave irradiation,in proportional to the applied field power and working time. Conclusions Elasto-ultrasonography helps to demonstrate microwave-induced lesion in porcine liver got rapidly hardened. It is possible to estimate the tissue necrosis to the changing of tissue hardening.