The value of brain natriuretic peptide in connective tissue diseases associated with pulmonary arterial hypertension
10.3760/cma.j.issn.0578-1426.2011.02.005
- VernacularTitle:B型利钠肽在结缔组织病相关肺动脉高压中的诊断价值
- Author:
Zhuang TIAN
;
Xiaoxiao GUO
;
Mengtao LI
;
Qian WANG
;
Yongtai LIU
;
Jiuliang ZHAO
;
Quan FANG
;
Xiaofeng ZENG
- Publication Type:Journal Article
- Keywords:
Connective tissue diseases;
Hypertension,pulmonary;
Natriuretic,peptide;
N-terminal pro-brain peptide
- From:
Chinese Journal of Internal Medicine
2011;50(2):102-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential role of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide(NT-proBNP) in the assessment of patients with connective tissuediseases(CTD) associated pulmonary arterial hypertension (PAH). Methods Thirty patients with CTD associated PAH were evaluated by WHO function, echocardiography, right heart catheterization and blood biomarkers. All the clinical data was analyzed statistically. Results All patients [age (39.5 ± 11.6) yr]were female. Both NT-proBNP and BNP were significantly increased and significantly correlated ( all P ＜0. 05 ) respectively with mean pulmonary arterial pressure ( r = 0. 53 and r = 0. 40 ), right arterial pressure ( r = 0. 55 and r = 0. 42 ), pulmonary vascular resistance ( r = 0. 69 and r = 0. 61 ), cardiac index ( r = - 0. 58and r = - 0. 46), mixed venous blood oxygen saturation ( r = - 0. 62 and r = - 0. 54 ), pericardial effusion ( r = 0. 46 and r = 0. 43 ), right atrial sizes ( r = 0. 40 and 0. 53, and r = 0. 39 and 0. 45 ) and right ventricular size ( r = 0. 55 and r = 0. 37 ). Furthmore, NT-proBNP, but not BNP, significantly correlated with WHO function class ( r = 0. 55 ). Conclusion Blood NT-proBNP and BNP were elevated in patients with CTD associated PAH and paralleled the extent of function class, pulmonary hemodynamic changes and right ventricular remodeling.
