Expressions and significance of two kinds of vascular endothelial growth factors of different origin in adrenocortical lesions of primary aldosteronism
10.3760/cma.j.issn.1000-6699.2011.01.004
- VernacularTitle:原发性醛固酮增多症肾上腺皮质病变中两种来源的血管内皮生长因子的表达及意义
- Author:
Wen CHEN
;
Zuojie LUO
;
Yingfen QIN
;
Xinghuan LIANG
;
Decheng LU
;
Jing XIAN
;
Li JIANG
- Publication Type:Journal Article
- Keywords:
Primary aldosteronism;
Adrenocortical diseases;
Vascular endothelial growth factor,endocrine gland derived
- From:Chinese Journal of Endocrinology and Metabolism
2011;27(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of the endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and vascular endothelial growth factor(VEGF) in adrenocortical lesions of primary aldosteronism. Methods The expressions of EG-VEGF, and VEGF were detected by immunohistochemistry and real-time fluorescence quantitative PCR in samples of 18 cases of adrenocortical adenoma, 6 adrenocortical hyperplasia, and 8 normal adrenal cortex. The correlation between the expressions of EG-VEGF, VEGF, and clinicopathological parameters was analyzed. Results The expression of EG-VEGF or VEGF in adrenocortical adenomas was higher than that in adrenocortical hyperplasia or normal adrenal cortex ( all P＜0. 05 ), and the expression of EG-VEGF or VEGF between adrenocortical hyperplasia samples and normal adrenal cortex samples was indistinctive. There was no statistically significant correlation between EG-VEGF or VEGF expression and sex, age, blood pressure, serum potassium, plasma renin activity, except in case of serum aldosterone( P＜0.05 ). A positive correlation between EG-VEGF and VEGF ( P＜0. 01 ) was found. Conclusions EG-VEGF and VEGF may play a significant role in the formation and development of adrenocortical tumors in primary aldosteronism.
