Advances in research of NF-κB signal transduction in gastrointestinal cancer
10.3760/cma.j.issn.1673-422X.2011.02.020
- VernacularTitle:转录核因子-κB信号传导在消化道肿瘤中的研究进展
- Author:
Jiaqi DAI
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Signal transduction;
Digestive system neoplasms
- From:
Journal of International Oncology
2011;38(2):142-144
- CountryChina
- Language:Chinese
-
Abstract:
NF-κB a factor possessing multiple transcription functions, has been demonstrated to have relation with the imbalance between cell proliferation and apoptosis in stomach, intestines, liver and other tissues of digestive tract. The active NF-κB signal transduction is extensively involved in the precancerous lesion,rumor development and invasion and metastasis. The therapies aimed at the activation of NF-κB can promote apoptosis of tumor cells, reduce the resistance against chemo-radiotherapy and relieve the cachexia caused by tumor.
