Relationship between PI3K-Akt signaling pathway and ovarian cancer
10.3760/cma.j.issn.1673-422X.2011.02.024
- VernacularTitle:PI3K/Akt信号通路与卵巢癌的关系
- Author:
Shengmin CHEN
;
Xiaolin PAN
;
Feng LI
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Signal transduction;
Drug therapy
- From:
Journal of International Oncology
2011;38(2):155-157
- CountryChina
- Language:Chinese
-
Abstract:
Positive regulative factors of PI3K/Akt signaling pathways is often activated in ovarian cancer, whereas the function of negative regulator PTEN is often defective. These two kinds of regulators cooperatively regulate tumor cell proliferation and apoptosis in closely association with tumor angiogenesis and invasion and metastasis. It has been suggested that PI3K-Akt pathway is not only related to prognosis of tumor patients but can also be used as novel targets for tumor therapy.
