Retrospective study on the initial clinical manifestations of 1958 hospitalized patients with systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2011.02.009
- VernacularTitle:1958例系统性红斑狼疮住院患者首发表现和起病特点的回顾分析
- Author:
Yufan GUO
;
Lingyun SUN
;
Yaohong ZOU
;
Wenyou PAN
;
Xiangdang WANG
;
Jieping PAN
;
Miaojia ZHANG
;
Juan TAO
;
Yu ZHANG
;
Kuilin TAN
;
Jing LI
;
Xiang DING
;
Xian QIAN
;
Zhanyun DA
;
Meimei WANG
;
Zhiwei CHEN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Retrospective studies;
Clinial manifestation
- From:
Chinese Journal of Rheumatology
2011;15(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the initial manifestation and disease onset feature of systemic lupus erythematosus(SLE) in the past ten years in fifteen hospitals in Jiangsu Province.Methods Data was collected by the same Methodsin all the participated hospitals and then it was summarized for retrospective analysis.Two groups were compared by chi-square test.Results ① One thousand nine hundred and fifty eight patients were investigated and the male-to-female ratio was 1∶15.0.② One thousand seven hundred and ninty eight patients had clear initial manifestations.The most common initial manifestations were skin and mucosal lesions(769 cases,42.8％ ) and arthritis (697 cases,38.8％ ).The main skin lesion was malar rash (706 cases).Arthritis was found to be more common in female than male.③ All hospitalized patients at their first admission showed multiple organ/system involvement:the most common involvement was skin and mucous membrane (82.3％),hematologic damage (74.0％),in which at least one series of blood cells were involved,arthritis (1156 cases,56.5％ ) much more than myositis (51 cases),proteinuria 1046 cases and hematuria in 385 cases.Renal biopsy pathology showed type Ⅳ glomerulonephritis.Conclusion ① SLE patients are mainly female and the male to female ratio is 1∶15.0.② The most common initial manifestations are skin and mucosal lesions.③ The most commonly involved organ/system are skin and mucous membrane,blood,joint and kidney.The most common pathological changes shown in renal biopsy is type Ⅳ glomerulonephritis.
