Efficacy of dirithromycin and clarithromycin in treatment chronic sinusitis

VernacularTitle:地红霉素与克拉霉素治疗慢性鼻窦炎疗效观察
Author: Jing JIN ; Jun LI ; Linfeng YE ; Xianglei WU
Publication Type:Journal Article
Keywords: Sinusitis; Anti-bacterial agents
From: Chinese Journal of General Practitioners 2011;10(3):202-204
CountryChina
Language:Chinese
Abstract: Fifty four patients with chronic sinusitis (without nasal polyps) were randomly divided into two groups. Thirty patients in experimental group were treated with dirithromycin and 24 patients in control group were treated with clarithromycin. The doses was both 250 mg q. d. and the duration of treatment was 3to 6 months. The VAS scores of subjective symptoms (nasal obstruction, purulent nasal discharge,headache, smell worse ) and Lund-Mackay scores of objective signs (sinus CT ) in both groups were improved significantly compared with the baseline(P ＜0.05), and there were no statistical significances between two groups ( P ＞ 0. 05 ). The curative effect was positively correlated with the duration of treatment.The total effective rates were 73% and 67% and adverse reaction rates 7% and 21% in two groups,respectively (P ＞ 0. 05 ); but the adverse reactions in control group were more serious than those in experimental group. During the six-month follow-up, no recurrence and aggravation were observed. The results suggest that low-dose dirithromycin may be more suitable for long-term treatment of chronic sinusitis.