An analysis of hyperinsulinemia in Bartter syndrome
10.3760/cma.j.issn.0578-1426.2011.02.011
- VernacularTitle:Bartter综合征中的高胰岛素血症
- Author:
Shi CHEN
;
Zhengpei ZENG
;
Anli TONG
;
Lin LU
;
Ailing SONG
;
Wei LIANG
;
Yong FU
;
Weibo XIA
;
Yan JIANG
;
Jiangfeng MAO
;
Huabing ZHANG
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Hyperinsulinism;
Insulin resistance;
Bartter syndrome
- From:
Chinese Journal of Internal Medicine
2011;50(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analys hyperinsulinemia in Bartter syndrome. Methods Twenty-three cases of Bartter syndrome [age (27 ±9) years;fasting serum potassium(2. 8 ±0. 5)mmol/L], 20 patients of aldosterone-producing adenoma [APA, age (45 ± 11 ) years, fasting serum potassium ( 3.0 ± 0. 4 ) mmol/L], 20 patients of idiopathic hyperaldosteronism [IHA, age (51 ± 11 ) years, fasting serum potassium (3.4 ±0. 2)mmol/L] were diagnosed in Peking Union Medical College Hospital from September 2003 to May 2008. All patients underwent 3-hours oral glucose tolerance test(3hOGTT), postural stimulation test and calculated HOMA-insulin resistance ( HOMA-IR ) and HOMA-insulin sensitivity ( HOMA-IS ) by Homeostasis model.Results The insulin area under curve-(229.0±162.4)mIU·L-1·h] was singnificantly higher than APA group [(227.7±158.6)mIU·-1·h].But HOMA-IR in Bartter group were similar to APA group( 1.96 ± 1.14 vs 1.41 ± 0. 91 ), and HOMA-IR in APA group was lower than IHA group ( 1.96 ± 1.14 vs 2.40 ± 1.60, P ＜ 0. 05 ). There was no deference in HOMA-IS among three groups,but APA group had lower level. In all three groups, the peak of insulin secretion was delayed. Conclusion Bartter syndrome patients commonly present with hyperinsulinemia.
