The effects of combination anti-inflammatory and anti-oxidation drugs in acute stroke
10.3760/cma.j.issn.0578-1426.2011.02.014
- VernacularTitle:抗炎与抗氧化联合治疗在卒中急性期的应用
- Author:
Qi BI
;
Zhe SONG
- Publication Type:Journal Article
- Keywords:
Stroke;
Atherosclerosis;
Prognosis
- From:
Chinese Journal of Internal Medicine
2011;50(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective Research the effect of anti-inflammatory and anti-oxidation drugs on acute stroke patients. Methods 128 patients with acute ischemic stroke are divided into two groups- combined treatment group (71) and control (57). Test serum biomarkers and evaluate neurological function and living ability before and after therapy, compare between groups and intra-group. To observe the effects of combined therapy on serum biomarkers and prognosis in acute stage. Results ( 1 ) MMP-9 of combined treatment group (3.23 ±0. 99) ng/L is higher than control (2. 82 ± 4. 21 )ng/L before therapy (P ＜0. 05). (2) The level of pre-treatment ox-LDL-Ab in combined treatment group ( 0. 08 ± 0. 01 ) U/ml higher than posttreatment (0. 07 ±0. 01 ) U/ml (P ＜ 0. 05 ). The level of pre-treatment NIHSS in control group (5.76 ±6.61) score higher than post-treatment (4.22 ±5.45) score,P＜0.05. Conclusion Combined treatment can degrade serum MMP-9 and ox-LDL in acute ischemic stroke patients, but it can't obviously improve the earlier prognosis.
