Mechanism and expression of KLF6 tumor suppressor gene in related tumors
10.3760/cma.j.issn.1673-422X.2011.02.006
- VernacularTitle:抑癌基因KLF6的作用机制及其在相关肿瘤中的表达
- Author:
Xiuwen ZHANG
;
Guohai ZHAO
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Gene expression;
Kruppel-like factor 6
- From:
Journal of International Oncology
2011;38(2):99-102
- CountryChina
- Language:Chinese
-
Abstract:
It has been revealed that the major mechanism of KLF6 is to upregulate p21 in an p53-independent manner leading to inhibition of cell proliferation. Lacking of KLF6 activity or its abnormal expression may be related to multiple tumors'development and prognosis such as prostate cancer, liver cancer, gastric cancer and other tumors. Furthermore, KLF6 may become a novel candidate for molecular target therapy.
