Correlation of methylation of E-cad gene with gastrointestinal cancer
10.3760/cma.j.issn.1673-422X.2011.02.021
- VernacularTitle:E-cad基因甲基化与消化道肿瘤的相关性
- Author:
Yongli LI
;
Guojin DING
- Publication Type:Journal Article
- Keywords:
E-cadherin;
Gene;
Methylation;
Gastrointestinal cancer
- From:
Journal of International Oncology
2011;38(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
The methylation of CpG island in promoter region of E-cad gene which usually leads to inactivation of E-cad gene is closely related to the occurrence, development, invasion, metastasis and prognosis of a variety of gastrointestinal cancer, such as esophageal carcinoma, gastric carcinoma, hepatocellular carcinoma,cholangiocellular carcinoma, carcinoma of gallbladder, pancreatic carcinoma and colorectal cancer. Further study would probably guide the early diagnosis, gene therapy, prophylaxis and predicting recurrence of tumor metastasis of gastrointestinal cancer.
