Study the effects of losartan on brain natriuretic peptide and C-reactive protein in diabetic cardiomyopathy patients
10.3760/cma.j.issn.1673-4904.2011.07.010
- VernacularTitle:氯沙坦对糖尿病心肌病患者脑钠肽和C反应蛋白的影响研究
- Author:
Ziqing ZHU
;
Shijie CHENG
;
Huimin YING
- Publication Type:Journal Article
- Keywords:
Losartan;
Diabetic cardiomyopathy;
Brain natriuretic peptide;
C-reactive protein
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(7):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects oflosartan on brain natriuretic peptide(BNP)and C-reactive protein(CLRP)in diabetic cardiomyopathy patients. Methods Sixty diabetics were divided into diabetic control group(30 cases)and diabetic cardiomyopathy group(30 cases), and the levels of BNP and CRP in plasma were determined. Then, diabetic cardiomyopathy group were divided into conventional treatment group(15 cases)and losartan treatment group(15 cases)by random digits table to take corresponding treatment for 12 weeks. The changes of cardiac function, the levels of BNP and CRP in plasma were detected and compared. Results The levels of BNP and CRP in diabetic cardiomyopathy group [(331.27 ±65.64)ng/L,(26.10±10.13)mg/L]were significantly higher than those in diabetic control group[(76.09±39.14)ng/L,(7.03±2.71)mg/L](P＜0.01). After treatment 12 weeks, the levels of BNP and CRP were significantly lower, left ventricular ejection fraction was significantly higher and left ventricular end-diastolic diameter was significantly lower in losartan treatment group than those in conventional treatment group(P＜0.05).Conclusions The increasing levels of BNP and CRP can reflect clinical severity of diabetic cardiomyopathy.Losartan can decrease the levels of BNP and CRP, and improve heart function, and it has better effective on diabetic cardiomyopathy.
