The effects of pravastatin on serum adipocytokines in patients with IGT and metabolic syndrome
10.3760/cma.j.issn.1008-1372.2011.02.013
- VernacularTitle:普伐他汀对糖耐量受损合并代谢综合征患者脂肪细胞因子的影响
- Author:
Peng LIU
;
Yingying CHEN
;
Ziliang WANG
;
Fengmei ZHANG
- Publication Type:Journal Article
- Keywords:
Pravastatin/PD;
Glucose intolerance/CO/DF/ME;
Metabolic syndrome X/CO/DT/ME;
Adipokines/ME
- From:
Journal of Chinese Physician
2011;13(2):188-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of pravastatin on the blood biochemical index,the levels of serum resistin,tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with impaired glucose tolerance (IGT) and metabolic syndrome (MS).Methods 60 patients with IGT and MS were random treated with pravastatin or remedial life-style intervention,and the levels of lipids profiles,insulin resistance index (HOMA-IR),serum resistin,TNF-α and IL-6 were measured before and after treatment.Results The levels of total cholesterol [ (4.45 ±0.60)mmol/L vs (5.58 ±0.96) mmol/L,t =-5.42,P ＜0.01],HOMA-IR [3.22 ±0.64 vs 3.58 ±0.71,t =-2.05,P ＜0.05) ],resistin[ (1.97 ±0.72) μg/L vs (2.76 ±0.73) μg/L,t=-4.26,P ＜0.01 ],TNF-α[ (9.36 ±2.03) μg/L vs (13.87 ±2.30)μg/L,t =-8.06,P ＜0.01] and IL-6[ (3.50 ±0.99) μg/L vs (6.32 ±1.17) μg/L,t =-10.06,P ＜0.01 ] in pravastatin group were significantly lower than those in life-style intervention group.Conclusion Pravastatin could improve insulin sensitivity of the patients with IGT and MS,significantly decreased the serum levels of resistin,TNF-α,IL-6,and it had anti-inflammatory effect.
