Analysis of the relationship between thrombomodulin changes and the score of the model for end-stage liver disease in liver cirrhosis patients
10.3760/cma.j.issn.1673-4904.2011.07.001
- VernacularTitle:肝硬化患者血栓调节蛋白与终末期肝病评分模型相关性分析
- Author:
Donglei ZHANG
;
Jianyu HAO
;
Ning YANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Thrombomodulin;
Model for end-stage liver disease
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(7):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between thrombomodulin(TM), fibrinolytic system changes and the score of the model for end-stage liver disease(MELD)in liver cirrhosis patients.Methods Eighty-five liver cirrhosis patients admitted from January 2008 to December 2009 were included in this study. TM, D-dimer, tissue plasminogen activator(t-PA), plasminogen activator inhibitor -1(PAI-1),serum creatinine, serum total bilirubin and international normalized ratio(INR)on all patients were measured and then the score of the MELD was calculated. Results The score of the MELD was 1-29(11.35 ± 6.02)scores. The score of the MELD ≤ 9 scores was 40 cases(47.1%), 10- 19 scores was 32 cases (37.6%),20-29 scores was 13 cases(15.3%).TM and D-dimer were progressively increased with MELD score. There was significant difference among the three groups(P＜0.01). The levels of TM and D-dimer had positive correlation with the score of the MELD(r = 0.706,0.425,P ＜ 0.01). Conclusions The levels of TM and D-dimer have positive correlation with the score of the MELD in liver cirrhosis patients. These indices can help predicting the degree of liver function disorder and prognosis.
