Association of HLA-A and -B alleles with syphilis in Shandong Han population
10.3760/cma.j.issn.0412-4030.2011.02.018
- VernacularTitle:山东汉族梅毒患者与HLA-A、B等位基因的相关性研究
- Author:
Hongwei JIANG
;
Hongqing TIAN
;
Zhongwei LI
;
Na LI
;
Yi ZHAO
;
Dianchang LIU
;
Bing LIU
;
Tongsheng CHU
;
Hong LIU
;
Jianling HOU
;
Rongtao ZHENG
- Publication Type:Journal Article
- Keywords:
Syphilis;
HLA antigens;
Alleles
- From:
Chinese Journal of Dermatology
2011;44(2):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of HLA-A and -B alleles with syphilis in Shandong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5844 normal human controls by PCR-sequence specific oligonucleotide probe (PCR-SSOP)method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles(all P＜0.01, Pc＜0.05) and a lower frequency of HLA-A*26 allele (P= 0.003, Pc = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P＜0.01, Pc＜0.05), as well as an elevated frequency of HLA-A*02, 11, 29, B*15 and 40 alleles (all P＜0.01, Pc＜0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatic syphilis(P=0.002, 0.026, Pc=0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatic syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to be an association between HLA-A*02, B* 15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptom1atic syphilis, in Shandong Han population.
