The clinical and magnetic resonance imaging studies of brain damages in neuromyelitis optica
10.3760/cma.j.issn.0578-1426.2011.03.005
- VernacularTitle:视神经脊髓炎患者脑损害的临床和神经影像学特点
- Author:
Hui SUN
;
Jing YE
;
Zhangyuan LIAO
;
Cunjiang LI
;
Xiaofan YOU
;
Kuncheng LI
;
Yaou LIU
;
Yunyun DUAN
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Brain damage;
Magnetic resonance imaging
- From:
Chinese Journal of Internal Medicine
2011;50(3):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feature brain damage and clinical manifestations in neuromyelitis optica (NMO) patients; To investigate the relationship between serum NMO-IgG antibody and NMO brain damage. Methods Clinical data of 37 NMO patients and their head and spinal cord MRI by 1.5T superconducting MR scanner, were analyzed; serum NMO-IgG antibody were measured by immunofluorescence. Results 17 cases were found to have abnormal signals on MRI, which were mainly in the white matter, pons, medulla, ventricle, aqueduct, and around the corpus callosum; According to pathological changes, brain damage can be divided into scattered irregularity (13 cases), fusion (3 cases),multiple sclerosis-like (1 case) ,with scattered irregularity more common,5 cases had clinical manifestations of brain damage: somnolence, vomiting, diplopia, visual rotation, 11 cases patients with brainstem damage show positive serum NMO-IgG antibodies. Conclusions Brain damage can be seen in half of NMO patients, they often located in the high expression area of AQP4: brain white matter, periventricular,brainstem and so on. Clinical symptoms has nothing to do with the size of lesions but the location, they often occur when brainstem was involved. Serum NMO-IgG is helpful in differentiating NMO with brain damage and MS.
