A clinical analysis of 61 cases of protein-losing enteropathy
10.3760/cma.j.issn.0578-1426.2011.03.009
- VernacularTitle:蛋白丢失性肠病61例临床分析
- Author:
Liming ZHU
;
Gang SUN
;
Jiaming QIAN
;
Xiucai FANG
;
Guijun FEI
;
Huijun SHU
;
Tao GUO
;
Yue LI
- Publication Type:Journal Article
- Keywords:
Protein-losing enteropathies;
Lymphangiectasis;
99Tcm-labelled human serumalbumin scintigraphy
- From:
Chinese Journal of Internal Medicine
2011;50(3):209-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To increase the understanding in protein-losing enteropathy (PLE).Methods Sixty-one PLE patients were enrolled in the study and the clinical characteristics, complicated disease, diagnosis and treatment were analyzed. Results The age of the patients was 16-77 (40±15)years, and the gender ratio was 35:26 (female: male). The main clinical manifestations were bilateral lower limb edema in 51 cases, ascites in 41 cases, bilateral pleural effusion in 23 cases, pericardial effusion in 13cases, abdominal pain in 16 cases and diarrhea in 33 cases. The prominent abnormality in laboratory examinations was hypoalbuminemia. The underlying diseases include systemic lupus erythematosus (SLE) in 28 cases, intestinal lymphangiectasia in 12 cases, hepatic cirrhosis in 5 cases, heart diseases in 5 cases,Crohn's disease in 3 cases, membranous nephropathy in 2 cases, Budd-Chiari syndrome in 1 case. Four cases happened after abdominal operation and 1 case after radiation therapy of gastric cardia cancer. Thirtyseven cases were diagnosed by 99Tcm-labelled human serum albumin scintigraphy and 24 cases were diagnosed clinically. Treatment was focused on underlying diseases. The clinical manifestations in 21 cases of SLE improved after SLE was controlled. In 2 cases of intestinal lymphangiectasia and one with Crohn's disease, the clinical manifestations improved after surgery. The other patients had no improvement.Conclusions PLE was not uncommon in clinical practice. Its predominant characteristics were severe hypoalbuminemia, edema and dropsy of serous cavity. PLE can complicate other diseases such as SLE,intestinal lymphangiectasia. Treatment should be focused on primary disease.
