Correlation between plasma visfatin levels and type 2 diabetes mellitus with carotid atherosclerosis
10.3760/cma.j.issn.1008-1372.2011.02.015
- VernacularTitle:血浆内脏脂肪素水平与2型糖尿病并颈动脉粥样硬化的相关性研究
- Author:
Zhaoliang LI
;
Juan XU
- Publication Type:Journal Article
- Keywords:
Viscera/ME;
Fats/ME;
Adipokines/ME;
Diabetes mellitus,type 2/CO/ME;
Arteriosclerosis/CO/ME;
Carotid artery diseases/CO/ME
- From:
Journal of Chinese Physician
2011;13(2):194-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between plasma visfatin levels and type 2 diabetes mellitus patients with carotid atherosclerosis.Methods 60 subjects were divided into 3 groups,T2DM no carotid atherosclerosis group (20 cases),T2DM with carotid atherosclerosis group (20 cases)and normal control group (20cases).Carotid IMT,plasma visfatin,waist circumference (WC),fasting plasma glucose (FPG),HbA1C,blood lipids,fasting serum insulin (FINS) were assayed or measured in all subjects.Results Plasma visfatin levels in T2DM with carotid atherosclerosis were significantly higher than those in normal control group and T2DM group [ (50.85 ± 20.14) ng/ml vs (18.50 ± 4.60) ng/ml,(50.85 ±20.14) ng/ml vs (35.52 ± 10.18) ng/ml,F = 105.983,P ＜0.01].Correlation analysis showed that plasma levels of visfatin were positively correlated with carotid IMT(r =0.476,P ＜0.01),TG (r =0.328,P ＜0.01),WC (r =0.206,P ＜0.05) and it was negatively correlated with HDL-C(r=-0.298,P ＜0.01).Conclusion Plasma visfatin was correlated with the development of macrovascular complications in T2DM patients,and it might be involved in the atherosclerotic pathological and physiological basis.
