Advances in relationship between WNT5A and neoplasms
10.3760/cma.j.issn.1673-422X.2011.02.001
- VernacularTitle:WNT5A与肿瘤的关系
- Author:
Xiaolei ZHANG
;
Jianhua ZHENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Signal transduction;
WNT5A
- From:
Journal of International Oncology
2011;38(2):83-86
- CountryChina
- Language:Chinese
-
Abstract:
WNT5A is associated with embryonic development and the development, invasion, metastasis and chemoresistance of tumor cells. The WNT5A signal in different tumors is specifically mediated by a number of factors, including receptors, downstream targets, inhibitors and external influences from tumor microenvironment and extracellular matrix. Eventhough it is still under debate whether WNT5A functions as a tumor suppressor or a promoter, WNT5A signal transduction pathway is closely associated with various tumor behaviors.
