Association of multidrug resistance gene MDR1 C3435T polymorphism with tumor incidence and treatment outcome
10.3760/cma.j.issn.1673-422X.2011.02.002
- VernacularTitle:C3435T多态性与肿瘤发病风险及疗效的关系
- Author:
Ziying JIAN
;
Baoan CHEN
- Publication Type:Journal Article
- Keywords:
Drug resistance,multiple;
Breast neoplasms;
Stomach neoplasms;
Colorectal neoplasms
- From:
Journal of International Oncology
2011;38(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance gene MDR1 C3435T polymorphism influences tumor incidence and treatment outcome. Carcinogenic substances are easier to accumulate in tissue for T allele patients, so TT genotype patients are more likely to develop into breast neoplasms, stomach neoplasms and colorectal neoplasms.Besides, the chemotherapy treatment outcome for patients with both C3435T TT genotype and wild-type KRAS is the best. However, due to ethnic, regional and sample differences, the relationship between C3435T polymorphism and stomach neoplasms 、colorectal neoplasms is still unclear.
