Roles of periostin in cancer
10.3760/cma.j.issn.1673-422X.2011.02.004
- VernacularTitle:Periostin在肿瘤中的作用
- Author:
Rong YANG
;
Fusheng WU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Angiogenesis inducing agents;
Periostin
- From:
Journal of International Oncology
2011;38(2):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Periostin, a extracellular matrix protein structurally similar to fasciclin proteins, is expressed specifically in various tumor tissues and correlates with tumor progression and prognosis. Periostin prevents the apoptosis of tumor cells, promotes tumor growth and can induce angiogenic signaling cascades through αvβ3-FAK and Flk-1/KDR. It also contributes to epithelial-mesenchymal-transformation promoting tumor invasion and metastasis. Periostin maybe a potential therapeutic target of cancer treatment.
