CCL21/CCR7 axis and mechanisms of tumor invasion and metastasis
10.3760/cma.j.issn.1673-422X.2011.02.005
- VernacularTitle:CCL21/CCR7轴与肿瘤侵袭转移的机制
- Author:
Kai CUI
;
Bo ZHANG
;
Sheng LI
- Publication Type:Journal Article
- Keywords:
Chemokine CCL21;
Receptors,CCR7;
Neoplasm metastasis;
Lymphatic metastasis;
Signal transduction
- From:
Journal of International Oncology
2011;38(2):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Secondary lymphoid tissue chemokine (CCL21) is a double-edged sword, which exerts antitumor, anti-infection immune response by binding to the receptor CCR7 on the surface of the multiple immune cells. However, a variety of tumor cells also express the receptor CCR7, the combination of CCL21 with CCR7promotes the invasion and metastasis of tumor cells, leading to the facilitation of tumor development. Therefore,exploring the mechanism(s) of tumor invasion and metastasis might be helpful for use of CCL21 as tumor gene therapy through blocking of CCL21's promotion of tumor invasion and metastasis.
