Current research status of TOP2A gene with response to anthracycline-based chemotherapeutic agents in breast cancer
10.3760/cma.j.issn.1673-422X.2011.02.015
- VernacularTitle:乳腺癌TOP2A基因与蒽环类药物疗效
- Author:
Xuyuan LI
;
Weibing LI
;
Yingcheng LIN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
DNA topoisomerases,type Ⅱ;
Anthracyclines
- From:
Journal of International Oncology
2011;38(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Anthracycline-based chemotherapeutic agents were extensively applied to the treatment of breast cancer. The relation of its response to TOP2A gene was proved by a number of clinical studies demonstrating that patients with both HER2 gene amplification and TOP2A gene aberration have a favored outcome,but a consensus was not yet achieved.
