Clinical study of intermittent deferoxamine therapy on relieving iron overload in senile with transfusion
10.3760/cma.j.issn.1673-4904.2011.06.006
- VernacularTitle:间歇应用去铁胺治疗老年人输血相关性铁负荷过重的临床研究
- Author:
Yanjun WANG
;
Xueyong ZHANG
;
Linli PAN
;
Jie WU
;
Ting WANG
- Publication Type:Journal Article
- Keywords:
Deferoxamine;
Aged;
Ferritins;
Iron overload
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(6):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and safety of the intermittent deferoxamine therapy on relieving iron overload caused by transfusion in senile. Method Twenty-three senile with iron overload caused by transfusion were administered in a total daily dose of 20 - 50 mg/ ( kg·d ) for 5 - 6 days per week every 4 -6 weeks,the maximal dose was 2000 mg/d, add in 0.9％ sodium chloride 500 ml, continuous intravenous drip for 6 h. Result Nine months after therapy, serum ferritin fell from (2771.5±735.3)μg/L to (2483.7 ±724.4) μg/L (P＜0.01), and urine ferritin elevated from (9.68 ±5.39)μg/L to (12.14±5.50) μ g/L (P＜0.01 ). Conclusion It shows that intermittent deferoxamine therapy can reduce the serum ferritin with no significant toxicity.
