The correlation between aspirin resistance in patients with diabetes and AGEs and HOMA-IR
10.3760/cma.j.issn.1671-0282.2011.02.021
- VernacularTitle:糖尿病患者阿司匹林抵抗与糖基化终产物及胰岛素抵抗指数的相关性
- Author:
Yongxia LI
;
Dongcheng SHI
;
Lijuan YAN
;
Rile GE
;
Jiamei JIANG
;
Liu YANG
;
Jian SUN
;
Qiming FENG
- Publication Type:Journal Article
- Keywords:
Diabetes Mellitus;
Aspirin;
Resistance;
AGEs;
HOMA-IR;
Platelet;
Platelet aggregation
- From:
Chinese Journal of Emergency Medicine
2011;20(2):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence of aspirin resistance (AR) in patients with Type Ⅱ Diabetes mellitus (DM) and the correlation between AR and advanced glycosylation end products (AGEs) as well as the homeostasis model assessment for insulin resistance index (HOMA-IR). Methods A total of 69 patients with Type Ⅱ DM and another 23 patients without DM as control group were enrolled between October 2009 and July 2010. Blood lipid, blood routine, fasting blood glucose, Glycated hemoglobin (GHb/Hb A1c) ,fasting insulin were determined at first. After aspirin treatment for at least 7 days, platelet aggregation stimulated by arachidonic acid(AA) and adenosine diphosphate (ADP) were measured. In addition, the level of serum AGEs was measured by using ELISA assay. The degree of insulin resistance was obtained by using HOMA-IR. Results The incidence of AR in patients with Type Ⅱ DM was higher than that in the controls(30.4% vs. 8.7%, P = 0.037 ); the levels of serum AGEs and HOMA-IR in patients with Type Ⅱ DM were higher than those in the controls [ (359.56 ± 120. 14) pg/mL vs. (275.45 ± 118.06)pg/mL, P=0. 004; (4.42 ±4.78) vs. ( 1.5 ±0.78), P＜0.01, respectively]; platelet aggregation stimulated by AA in the diabetic group was correlated with serum AGEs and HOMA-IR( R =0.463, P ＜0.01; R=0.290, P =0.016, respectively); and platelet aggregation stimulated by ADP was only positively correlated with HOMA-IR(R =0.242, P = 0.045). Conclusions The incidence of AR in patients with Type Ⅱ Diabetes mellitus is higher than that in the controls, and diabetics with higher serum AGEs and HOMA-IR are more likely to develop aspirin resistant.
