Gastro-ducodenal injuries caused by nonsteroidal anti-inflammatory drugs
- Author:
Tran Ngoc An
- Publication Type:Journal Article
- Keywords:
Gastro-ducodenaf injuries;
Cause;
Nonsteroidal anti-inrflammatorydrugs
- MeSH:
Anti-Inflammatory Agents, Peptic Ulcer
- From:Journal of Medical Research
2005;34(2):33-39
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Clnical and endoscopic manifestations of gastro-duodenal injuries in 178 patients caused by nonsteroidal anti-inflammatory drugs (NSAID) were compared with these of 84 patients without treatment of NSAID. We concluded that abnomal rate in gastro-duodenal endoscopy is 86.0 % in the group treated by NSAID. Gastric injury rate is 80.9 %, including 22.5% of gastric ulcer (p<0.01). Duodenal injury rate is 29.2 %. including 22.5% of duodenal ulcer (p<0.01). Clinical features: epigastric pain rate is 42.7%; abdominal distention is 11.8%. These symploms are useful in predicting gastrointestinal injuries. These lesions more likely severe if the patient have following factors: above 60 years old; alcoholism, smosking, using NSAIDs for long time, using high dose of the NSAIDs. There is not relation between endoscopic manifestations, type of rheumatic disease and HP infections.
