VEGF mRNA expression in retinal neovascular tissue in rabbit eyes with retinal vein occlusion
- VernacularTitle:兔视网膜静脉阻塞眼视网膜新生血管组织中血管内皮生长因子mRNA的表达
- Author:
Hai LU
;
Huirong ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Ocular Fundus Diseases
2001;17(1):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the possible role of vascular endothelial growth factor (VEGF) in the pathogenesis of retinal neovascularization resulting from retinal ischemia． Methods Retinal vein occlusion of rabbits model was established with argon laser photocoagulation to retinal vein．The VEGF mRNA expression was observed in ischemic retina and retinal neovascular tissue with in situ hybridization technique． Results VEGF mRNA expression was detected in inner ischemic retina and retinal neovascular tissue that were corespondent to the distribution of retinal ischemia． The strongest VEGF mRNA expression was detected in retinal neovascular tissue． Conclusion VEGF might play an important role in the pathogenesis of vascular proliferative retinopathy．
