Effect of the 13-cis isotretinoin on androgen receptor levels in acneic patients

VernacularTitle:13-顺维甲酸对痤疮患者雄激素受体的影响
Author: Yan ZENG ; Sufang ZHANG ; Ren LI
Publication Type:Journal Article
From: Chinese Journal of Medical Aesthetics and Cosmetology 2001;7(1):17-18
CountryChina
Language:Chinese
Abstract: Objective　In order to explore the effect of 13-cis isotretinoin on androgen receptor in acneic patients and provide the theoretical basis for acne treatment. Methods　Radiological binding assay (RBA) was used to study the specific AR binding capacities between the experimental group and the control group before and after taking medicine. The serum testosterone level was measured with radioimmunoassay. Results　 16 weeks after taking medicine, the AR level in the acne patients decreased significantly compared with that before taking 13-cis RA (P＜0.05)，but the affinity change was not found, the testosterone levels did not evidently change either. Conclusion　The 13-cis RA can decrease the levels of AR and depress the hyperplasia of sebaceoous glands.