Protective effects of high-dose aprotinin on myocardial reperfusion injury
- VernacularTitle:大剂量抑肽酶对心肌缺血再灌注损伤的保护作用
- Author:
Cunzhen YUAN
;
Jin TANG
;
Zilin WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2001;17(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This study was designed to assess the protective effects of high-dose aprotinin on isolated rat hearts from ischemia-reperfusion injury. Method: The study consisted of two groups of rats. An isolated rat working heart model was established. Group A (n=16), received cardioplegia with high-dose aprotinin. Group B (n=16), received same cardioplegia only. The rat hearts were perfused for 30 minutes, then arrested for 40 minutes and reperfused for 30 minutes. The hemodynamic parameters, myocardial creatine kinase (CK) and myocardial ultrastructure were measured before ischemia and during reperfusion. Results: Recovery of cardial function, coronary flow and myocardial ultrastructure in group A was significantly better. CK level was lower in group A. Conclusion: High-dose aprotinin (1×106 KIU/L) may reduce myocardial ischemic and reperfusion injuries.
