Clinical studies of bacillus of Calmette-Guerin polysaccharide nucleic acid adjunctive therapy in pulmonary tuberculosis
10.3760/cma.j.issn.1673-4904.2011.07.004
- VernacularTitle:斯奇康注射液辅助治疗肺结核的临床研究
- Author:
Wenfeng LIN
;
Jin LI
;
Qihuang CHEN
- Publication Type:Journal Article
- Keywords:
Immunity,cellular;
Immunotherapy;
Tuberculosis,pulmonary;
Bacillus of Calmette-Guerin polysaccharide nucleic acid
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(7):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness, the influence on cellular immune function and the side-effect of bacillus of Calmette-Guerin polysaccharide nucleic acid(BCG-PSN)combined with antituberculous chemotherapy in the treatment of pulmonary tuberculosis. Methods A total of 60 pulmonary tuberculosis patients were divided into treatment group(30 patients)and control group(30 patients)by random digits table. All patients accepted the same standard antituberculous chemotherapy, meanwhile patients in treatment group were injected with BCG-PSN. Observed and compared the clinical symptom,the size of the focas nidus,the change of toxic response and immunity. Results The symptoms were significantly relieved in both groups after treatment(P＜0.05), but it was significantly better in treatment group(P＜0.05), the effective rate and control rate in treatment group[36.7%(11/30),96.7%(29/30)]were significantly higher than those in control group[23.3%(7/30), 86.7%(26/30)](P ＜ 0.05). After treatment,the levels of CD3,CD4 and IL-2 were higher, and the level of CD8 was lower, but the treatment group improved significantly better than control group(P ＜ 0.05). The rate of leukopenia was lower in treatment group than that in control group[10.0%(3/30)vs. 33.3%(10/30),P ＜0.05]. As to the safety,no other toxicities were observed in the treatment group. Conclusions BCG-PSN combined with antituberculous chemotherapy in the treatment of pulmonary tuberculosis contributes to relieve the symptom, reduce size of the nidus, decrease leukopenia incidence and enhance the cell immunity. It is safe.
